This article is an attempt to give scientific information about major HGH benefits to body including improvement of physique, fat loss, healing of cartilage, effects on immune and cardiovascular system.
If you are interested in using growth hormone this information about HGH benefits will help you to decide whether you need to use it or not.
Muscle growth HGH benefits
Anabolic properties of growth hormone are strong and they made it so popular among sportsmen, especially bodybuilders. HGH influences muscle via IGF-1, which is a result of growth hormone conversion in liver. IGF-1 binds to receptors in skeletal muscle tissue and in this way promotes protein synthesis.
Second way – is increasing number of nucleuses in muscle cells. Growth hormone induce transportation of miosatellite cells to already existing muscle cells. Miosatellites gives them their nucleuses and the muscle cell grows.
Increase number of muscle cells by their division
This effect is called hyperplasia – when one big muscle cell divides by two smaller ones. They, in turn, have more ability for hypertrophy than one cell. It seems to be the main among all HGH benefits, because significantly improves possible amount of muscles that you can gain.
Hyperplasia caused by HGH is likely to be the reason, why in 90-s bodybuilders became 15-20 kg heavier than in 80-s.
Growth hormone was proven to decrease oxidation of amino acids by 50 % during training  and similar decrease in amount of nitrogen in urine (it shows lower protein breakdown rate).
Growth hormone also prevents conversion of cortisone to cortisole, which is known to be main catabolic hormone.
Fat diminshing HGH benefits
Another great HGH benefit – ability to decrease fat even without keeping a diet.
How it works?
- Growth hormone makes fats available by pushing them into blood as free fatty acids (FFA). That is why organism starts to use them as energy and oxidate fat
- Converses thyroid hormone T4 to T3 form, which accelerates metabolism and is more active than T4
- Accelerates resting metabolic rate
These HGH benefits allow you to burn fat even without a calorie restriction – you can lose fat and gain muscles at the same time.
Famous experiment, which was published in New England Journal of Medicine, shows that 6 months of HGH treatment resulted in 14 % decrease in fat mass. This result was achieved without training or diet – only by using HGH. Obviously, if you train hard and eat clean, you will achieve more.
How HGH influences cartilage?
Increases bone density
Bone density is amount of minerals per square centimeter of bones. Bones become fragile, when bone density is low. When density is extremely low, person has osteoporosis. Growth hormone improve bone density by increasing level of collagen and osteocalcin.
Heals ligaments and joints
Most of the sportsmen have problems with joints and ligaments – pain and bad state of joints make training uncomfortable. Growth hormone can solve this problem – it accelerates rate of collagen and elastin synthesis, which results in joints improvement and ligament healing, because both of them consists mostly of these proteins
Strength of bones and joints help athlete to increase muscle strength.
HGH benefits for immune system
Immune cells, like others cells of body have receptors of IGF and can be enhanced by HGH.
- T-cells. This type of cells is produced by thymus and is responsible for the most of immune system functions. With aging thymus atrophy and its function worsens. However, HGH was found to return thymus its size and revive its functions. Scientists proved that people with growth hormone deficient have problems with thymus function and it can be restored if patients take exogenous HGH.
- NK-cells (natural killer cells)
Natural killer cells that complement T-cells are also can be stimulated by HGH. This function is still active even after GH treatment.
- B-cells. Growth hormone is able to augment immunoglobulin, thus stimulating B-cells to resist illnesses by secreting antibodies.
Expanding life period of cells
HGH benefits that allow to make cell younger and aging process slower have made growth hormone a popular drug in anti-aging therapy. Growth hormone prevents rapid death of cell when it doesn’t allow telomerase (life clock of cell) to shorten. As a result, cell is able to live longer.
Other benefits of HGH
- Diminishes level of cholesterol. Johan Verhelst and Roger Abs  research showed that growth hormone decrease total cholesterol level by 7 %. Especially, falls the level of bad cholesterol of very low density (VLDC)
- Betters sleep. Growth hormone improve quality of sleep – users claim that they sleep like babies. It results in better muscular and nervous recovery.
- Betters skin. Because of elastin and collagen synthesis, HGH makes skin cleaner and more elastic. It also helps to smooth age wrinkles and hydrate dehydrated skin of old people
- Improves cardiovascular function. Many studies of GH deficient people showed that they have significantly higher risk of heart failure and other cardiovascular diseases. People with GHD have bad lipid profiles, high level of cholesterol, fat concentrated in abdominal area etc.
experiment on rats performed by Renhui Yang  showed that GH helps to fight heart diseases and prevent occurance of new. It is partly because it increases cardiac index (ability of heart to pump blood well), stroke volume index (heart capacity to excrete blood), and left ventricular maximum (show strength of heart).
Mental benefits of growth hormone
- Improves vision.
- GH strengthens muscles that hold lenses
- Prevents from degeneration cells of retina
- Prevents cataract and glaucoma
- Better memory and cognitive function
Michael Vitiello and Baker LD  conducted experiments to evaluate how increasing level of HGH improves cognitive functions, particularly executive function, IQ and memory.
Results after 10 weeks of treatment showed significant rise in executive function (ability to concentrate, think rapidly, remember information connected with usual life), ability to memorize and solve intellectual tasks (IQ rise).
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1) D J O’Halloran, A Tsatsoulis, R W Whitehouse – Increased bone density after recombinant human growth hormone (GH) therapy in adults with isolated GH deficiency
2) Agnieszka M. Lichanska, Michael J. Waters – How growth hormone controls growth, obesity and sexual dimorphism
3) Franco Antoniazzi, MD Francesco Bertoldo, MD Monica Mottes, PhD – Growth hormone treatment in osteogenesis imperfecta with quantitative defect of type I collagen synthesis
4) Banks WA1, Morley JE, Farr SA – Effects of a growth hormone-releasing hormone antagonist on telomerase activity, oxidative stress, longevity, and aging in mice.
5) Growth Hormone to Increase Immune Function in People With HIV
6) Verrillo E1, Bizzarri C, Bruni O – Effects of replacement therapy on sleep architecture in children with growth hormone deficiency.
7) CP Velloso – Regulation of muscle mass by growth hormone and IGF-I
8) Philipp Dreifuss, MD – Cardiac Effects of Growth Hormone
9) Renhui Yang, MD; Stuart Bunting, PhD; Nancy Gillett, – Growth Hormone Improves Cardiac Performance in Experimental Heart Failure
10) Dr. Laura D. Baker, PhD, Ms. Suzanne M. Barsness – Effects of Growth Hormone–Releasing Hormone on Cognitive Function in Adults With Mild Cognitive Impairment and Healthy Older Adults
11) Fitzgerald, Susan – Can a Growth Hormone-Stimulating Drug Improve Cognitive Function?
12) Dr Ben Green MRCPsych FHEA – Human Growth Hormone In The Treatment Of Biological Depression
13) Michael V. Vitiello, PhD,* Robert S. Schwartz, MD, Karen E. Moe – Growth hormone releasing hormone improves the cognition of healthy older adults
14) Niels Møller and Jens Otto Lunde Jørgensen – Effects of Growth Hormone on Glucose, Lipid, and Protein Metabolism in Human Subjects
15) Dr. Daniel Rudman – HGH Injection Study in the New England Journal of Medicine
16) Johan Verhelst and Roger Abs – Cardiovascular risk factors in hypopituitary GH-deficient adults